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ACTOS(R) (pioglitazone HCl) Demonstrates Significant Improvements In...... in addition to standard-of-care treatment (including the routine use of anti-hypertensives such as ACE inhibitors and beta blockers; glucose-lowering agents such as metformin, sulfonylureas and insulin; antiplatelet drugs such as aspirin, and lipid- ... ACTOS (pioglitazone HCl) Demonstrates Significant Improvements in Cardiovascular Outcomes... in addition to standard-of-care treatment (including the routine use of anti-hypertensives such as ACE inhibitors and beta blockers; glucose-lowering agents such as metformin, sulfonylureas and insulin; antiplatelet drugs such as aspirin, and ... Takeda Pharmaceuticals North America, Inc.: ACTOS(R) (pioglitazone...... in addition to standard-of-care treatment (including the routine use of anti-hypertensives such as ACE inhibitors and beta blockers; glucose-lowering agents such as metformin, sulfonylureas and insulin; antiplatelet drugs such as aspirin, and ... 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